Acetyl Tetrapeptide-5 (Eyeseryl)

Acetyl Tetrapeptide-5, marketed under the trade name Eyeseryl, is a synthetic tetrapeptide specifically designed for the delicate periorbital (under-eye) area. The peptide was developed to address common cosmetic concerns including puffiness, bags under the eyes, and dark circles by targeting the underlying physiological mechanisms that contribute to fluid accumulation in periorbital tissue.

The primary mechanism of action involves the reduction of vascular permeability. As skin ages, blood vessel walls become more permeable, allowing fluid and blood components to leak into surrounding tissues. In the thin skin around the eyes, this increased permeability leads to edema (puffiness) and the accumulation of hemoglobin degradation products that contribute to dark discoloration. Acetyl Tetrapeptide-5 works by inhibiting angiotensin-converting enzyme (ACE) activity and glycation of proteins, both of which contribute to vascular leakage.

In vitro studies have demonstrated that Eyeseryl can reduce edema by decreasing the permeability of blood vessels. The peptide also exhibits anti-glycation properties, helping to prevent the cross-linking of proteins that contributes to tissue stiffening and impaired circulation in the periorbital area. Clinical studies on volunteers showed measurable reduction in under-eye puffiness after regular application.

The acetyl group at the N-terminus enhances stability and may improve skin penetration compared to unmodified peptides. Eyeseryl is commonly formulated in eye creams, gels, and specialized eye serums, often in combination with other cosmetic peptides and anti-aging actives targeting the eye area.